Yang’en You

FacultyName:Yang’en You

Title:Professor

Office:441,Shenghua Building

Email:chmyouy@hfut.edu.cn

Education:

B.S.,Chemistry, SoochowUniversity,2008-2012

Ph.D.,Organic Chemistry, Instituteof Chemistry, Chinese Academy of Sciences,2013-2018

Postdoc,Organometallics Chemistry, NationalUniversity of Singapore,2018-2022

Biography:

Yang’enwas born in Anhui, China. He received his bachelor degree inChemistry from Soochow University in 2012. Then, after a short timework at Chiral Quest Pharmacy Company in Suzhou, he began his Ph.D.study at ICCAS and obtained his Ph.D. degree in 2018 under thesupervision of Prof. Dr. Sanzhong Luo. During his Ph.D. study, hestudied chiral primary amine catalyzed asymmetric functionalizationof β-ketocarbonyl compounds, achieved the asymmetric fluorination ofbranched ketones catalyzed by chiral amine and the Mannich reaction,and discovered a chiral control mode based on electrostatic repulsionin amine catalysis and developed various imine precursor reagents forthe Mannich reaction with aldehydes and ketones.  From 2018 to 2022,he worked for Prof. Shaozhong Ge as a postdoc research fellow. Duringthis period, he developed base metal (such as Co, Cu, and Ni)catalyzed asymmetric hydroboration of unsaturated hydrocarbons andachieved cobalt-catalyzed one-pot asymmetric difunctionalization ofalkynes, as well as regioselective hydrosilylation/cylcization of1,6-enynes, and copper-catalyzed enantioselectivehydroaminomethylation of alkenes. In February 2022, he joined thedepartment of  applied chemistry at Hefei University of Technology asa Professor and his research primarily focus on the selectivetransformation of unsaturated hydrocarbons by base metal (Fe, Cu orCo) catalysis and cooperative catalysis (indobenzene and electronicco-catalysis).

ResearchInterests：

Organocatalysis,

Basemetal catalysis

Cooperativecatalysis

Electrocatalyticselective synthesis

TeachingInterests:

Organicsynthesis

GreenChemistry

FineChemicals

SelectedFunded Projects:

1. GrantNo. HZKY20220201, the Chunhui Project of the Ministry of Educationof China, 2023-2025.

2. GrantNo. 2308085QB42, Anhui Provincial Natural Science Foundation,2023-2025.

3. Thestart-up funds from Hefei University of Technology, 2022-2025.

SelectedAwards and Honors:

Meritstudent;

NationalScholarship for a Doctoral Graduate Student;

ExcellentDoctorate Graduates;

NamedScholarship;

SpecialAward for Youth Report;

TopPoster Award & Top Oral Report Award (multiple times).

SelectedPublications：

1. Yang'enYou,Long Zhang, Sanzhong Luo*. Reagent-Controlled EnantioselectivitySwitch in Asymmetric Fluorination of β-Ketocarbonyls by ChiralPrimary Amine Catalysis. Chem.Sci.2017,8,621.

2. Yang'enYou,Long Zhang, Linfeng Cui, Xueling Mi, Sanzhong Luo*. CatalyticAsymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates ofFormaldehyde and Glyoxylate. Angew.Chem. Int. Ed.2017,56,13814.

3. LinfengCui, Yang'enYou,Xueling Mi*, Sanzhong Luo*. Asymmetric Fluorination of α-BranchedAldehydes by Chiral Primary Amine Catalysis: Reagent-ControlledEnantioselectivity Switch. J.Org. Chem.2018, 83,4250.

4. LinfengCui, Yang'enYou,Xueling Mi*, Sanzhong Luo*. Catalytic Enantioselectiveα-Sulfenylation of β-Ketocarbonyls by Chiral Primary Amines. Org.Chem. Front.2018,5,2313.

5. Yang’enYou,Sanzhong Luo*. Catalytic Asymmetric Mannich Type Reaction withTri-/Difluoro- or Trichloroacetaldimine Precursors. Org.lett. 2018,20,7137.

6. Yang’enYou,Quyet Van Pham, Shaozhong Ge*. Copper-Catalyzed EnantioselectiveHydroaminomethylation of Alkenes with N,O-Acetals to Access Chiralβ-Stereogenic Amines: Dual Functions of the Copper Catalyst. CCSChem.2019,1,455.

7. Yang’enYou,Shaozhong Ge*. Asymmetric Cobalt-Catalyzed RegioselectiveHydrosilylation/Cylcization of 1,6-Enynes. Angew.Chem., Int. Ed.2021,60,12046.

8. Yang’enYou,Shaozhong Ge*. Cobalt-Catalyzed One-Pot AsymmetricDifunctionalization of Alkynes to Access Chiralgem-(Borylsilyl)alkanes. Angew.Chem., Int. Ed.2021,60,20684.(Hot paper).

9. JichengHou, Junhao Yin……Yang’enYou*.Regio- and stereoselective hydrochlorination/cyclization of1,n-enynes by FeCl₃catalysis. Org.Lett.2023,25,4359.

10. HaoLuo^#,Cong Lin^#,Yang-EnYou,…JunliangSun*, Zidong Wei*, Jin-Song Hu*. An ultralong single-crystallinenanoporous 3D transition metal-oxo framework nanowire family. Matter2023,6, 3598.